Promising pilot efficacy data of treating ovarian cancer patients with FRα-directed T cells was provided by a study of adoptive, intraperitoneal (IP) transfer of armed autologous T cells retargeted to FRα using a bispecific monoclonal antibody containing anti-CD3 and anti-FRα MOv18 F(ab’)2 fragments, in combination with IP interleukin-2 (IL-2) [34]. This evidence concerns the gene FOLR1 and ovarian carcinoma.