Most interestingly, exogenous expression of the versican G3 fragment in a mammary carcinoma 66 cl4 cell line (a cell line that expresses low levels of versican and normally metastasizes to the lung but not the bone) was sufficient not only to promote local tumor growth but also to enhance metastasis to bone from the mammary fat pad [22]. The gene discussed is VCAN; the disease is breast carcinoma.