We calculated that the minimum required sample size to find a statistically significant association between a MC1R variant and melanoma assuming a similar association to that observed in our previous meta-analysis [14] (Odds Ratio (OR) = 1.5) is around 7,500 cases and 7,500 controls for rare variants (1-2% allele frequency in controls), and 1,400 cases and 1,400 controls for common variants (8-10% allele frequency in controls), with 90% statistical power. This evidence concerns the gene MC1R and melanoma.