CD4 and cutaneous leishmaniasis: Similarly, Anderson et al [44] showed in a model of chronic cutaneous leishmaniasis caused by L. major that in addition to CD25+Foxp3+ Treg cells, IFN-γ-producing CD4+CD25−Foxp3− (Th1 cells) that co-produce IL-10 are more important than Tregs at regulating inflammation and disease chronicity.