Our present result of PES1 overexpression in colon cancer tissues complements previous studies and further suggests that PES1 is upregulated in multiple human cancers, raising the possibility that PES1 may serve as a universal tumor marker and a potential therapeutic target, while the clinical significance of PES1 overexpression in colon cancer tissues and the prognostic value of PES1 needs be defined in future studies. Here, PES1 is linked to neoplasm.