Multivariate analysis by Cox regression and correction for all histopathologic features and RhoT1 expression revealed that tumor differentiation was an independent prognostic factor (P = 0.01), whereas tumor stage, LNM and RhoT1 expression were not statistically significant (P = 0.623, P = 0.101, P = 0.3, respectively) (Table 5). This evidence concerns the gene RHOT1 and neoplasm.