We recently found that triterpenoid compounds isolated from bitter melon have potent efficacy in stimulating GLUT4 translocation in L6 myotubes and 3T3L1 adipocytes, along with activation of the AMPK pathway [14] Our acute studies in mice showed that triterpenoids are able to reduce glucose intolerance in insulin resistant high-fat (HF)-fed mice after a single injection [14]. The gene discussed is INS; the disease is Glucose intolerance.