We next examined total pancreatic insulin level and found that the administration of OA had no effect on the total pancreatic insulin content in T2D mice (29.1±10.6 vs. 26.6±6.0 μg/g pancreas in the T2D-Veh group, p>0.05) (Fig. 3B). This evidence concerns the gene INS and type 2 diabetes mellitus.