In addition, IL-17A varied as a function of the significant effect of CD4+CD25+ Treg cell depletion (F1, 39 = 26.51, p = 0.0001) and CIS (and F1, 39 = 17.56, p = 0.002), but there was no significant interaction between CD4+CD25+ Treg cell depletion and CIS (F1, 39 = 2.38, p = 0.1311) in the serum concentrations of IL-17A (Fig. 8B). The gene discussed is CD4; the disease is in situ carcinoma.