CCT can interact with a range of proteins, including Von Hippel-Lindau (VHL)-elongin BC tumor suppressor complex [54], cell-division cycle protein 20 (Cdc20) [55], sphingosine kinase 1 [56], Polo-like kinase 1 [57], HDAC3 [42], huntingtin [58], among others [59]. The gene discussed is VHL; the disease is breast cancer.