At an early stage of induction (23 days), although the sodium currents density was too low to fire action potentials, the changes of the membrane intrinsic properties (input resistant and membrane potential) and the expression of multiple neuronal makers (Tuj1, Map2, Neurofilament, NeuN and synapsin) indicated that glioma cells were truly altered to another type of cells. Here, RBFOX3 is linked to central nervous system cancer.