(1) The number of MCC cases with appropriate before/after specimens (n = 33 for intratumoral lymphocyte evaluation) is limited; (2) Complete spontaneous regression is relatively uncommon even in MCC; (3) If no tumor was present at the time of re-excision, the case could not be evaluated for ‘intratumoral’ infiltration of CD8+ cells. The gene discussed is CD8A; the disease is neoplasm.