LEPR and systemic lupus erythematosus: If decreased SOCS1 turns to be a reproducible feature of SLE, it could explain many of the systemic inflammatory and clinical features of SLE, including weight loss and cachexia, which could be due to impaired regulation of cytokine receptors, including IL-2R [49], IFNγR [50], type III IFN’s [51], IL-12 family receptors [52], [53], as well as toll like [54], and some non-immune receptors such as the leptin receptor [55].