SOCS3 and systemic lupus erythematosus: A study in Taiwanese SLE patients found an increased expression of CIS, but not SOCS1 or SOCS3 mRNA, whereas a second study in China, found that SLE patients as a whole had increased SOCS1 mRNA expression [48], looking at the latter study in depth it is clear that SOCS1 was increased only in active patients.