In SLE cells, the amount of SOCS1 bound to IFNAR1 and IFNAR2 was slightly lower than in controls, which is inverse with the amount of Jak1 bound, that was higher in SLE cells and remained bound even 6 hours after the addition of IFNβ, when Jak1 binding to IFNAR in healthy individuals was already subsiding. Here, JAK1 is linked to systemic lupus erythematosus.