Second, human variants of ADAMTS3 (locus 1) and PRKG2/BMP3 (i.e. immediately downstream of locus 2) are associated with adult height [29], [30], [31], a particular haplotype of NPFFR2 (locus 1) confers protection against obesity in Scandinavians [32] and the syntenic human segment overlapping locus 2 is associated with diastolic blood pressure [33]. This evidence concerns the gene BMP3 and obesity due to melanocortin 4 receptor deficiency.