In our meta-analysis, a statistically significant reverse association with gastric cancer was found among H. pylori positive cancer patients in contrast as H. pylori negative controls, but no statistically significant finding was found among H. pylori positive cancer patients in contrast as H. pylori positive controls (AA vs CA-plus-CC), indicating that IL-10-592 AA genotype may seem to be more protective from overall gastric cancer susceptibility in persons infected with H. pylori. This evidence concerns the gene IL10 and gastric cancer.