This hypothesis is supported by the work of Bednarski et al.29 who showed that doxorubicin induces cIAP2 in sarcoma cells, while the net effect of doxorubicin treatment was the apoptosis of the sarcoma cells (though in their case the compensatory effect was due to the downregulation of other anti-apoptotic genes). The gene discussed is BIRC3; the disease is sarcoma.