Our data, taken with a recent study that found miR-199a-5p was one of several miRNAs overexpressed in a small sample of brain-metastatic compared to primary colorectal carcinomas [46], invites speculation that miR-199a-5p has a role in the process of dissemination beyond its role in carcinogenesis, which could in part be due to modulation of Brm-type SWI/SNF activity [47]. Here, SMARCA1 is linked to colorectal carcinoma.