Higher serum adiponectin may be protective against cancer as an anti-proliferative through direct binding of other growth factors, such as platelet derived growth factor-BB (PDGF-BB), heparin-binding epidermal growth factor-like growth factor (HB-EGF), and basic fibroblast growth factor (basic FGF), hence restricting bioavailability [153]. Here, ADIPOQ is linked to cancer.