VEGFA and cancer: BR has also been investigated as an anti-cancer agent, reducing the mass and incidence of palpable tumours in adult malignant rat prostrate tumor cell (MAT-LyLu) inoculated Copenhagen rats [7] and repressing the production of pro-angiogenic factors like vascular endothelial growth factor (VEGF), matrix metalloproteinase 9 (MMP-9) and matrix metalloproteinase 2 (MMP-2) [8].