The TFs associated with the lower scoring modules listed in Table 6 include VDR, HAND1, GLI1, GLI2, PPARD, Lef1, FOXA2, GATA-1, REST, ITF-2, TF7L2, and SLUG. Out of this group, GATA-1 presents an example as a novel TF with a possible link to CRC. The gene discussed is LEF1; the disease is colorectal carcinoma.