The four chemotaxis-associated pathways were the CXR4 signalling pathway, inhibitory action of IL-8 and leukotriene B4-induced neutrophil-migration, and leukocyte and chemotaxis, all of which have been associated with CRC in literature[95,96], as well as Lipoxin inhibitory action of fMLP-induced neutrophil chemotaxis pathway. This evidence concerns the gene CXCL8 and colorectal carcinoma.