Comparison of the nodes obtained using only the topological features (Table 2) with those nodes obtained using both topological and biological features (Table 3)revealed that eight nodes were common to both: p53, c-Jun, STAT3, c-Myc, RARA, STAT1, ESR1, and STAT3. The unique nodes identified based on both features in Table 3 were ABL1, GL11, CDC6, ESR2, MK11, and PIAS1. Recent studies have identified GLI1 as highly up-regulated and PIAS1as down-regulated in CRC[68-71]. The gene discussed is ESR2; the disease is colorectal carcinoma.