Patient's condition worsens, with intense pallor, severe anemia (Hb = 5.3 g/dL, Ht = 16%), decreasing platelets (Plt = 90.000/mm3), increased liver enzymes (AST = 578 U/l, ALT = 732 U/l), elevated lactate dehydrogenase (600 U/l), and total bilirubin (BT = 3.5 mg/dL). The gene discussed is GSTM1; the disease is anemia.