Kanayama et al. [51] evaluated MMP-2, TIMP-2, and MT1-MMP in bladder cancer tissue using RT-PCR and found MMP-2 and TIMP-2 expression levels to be strongly associated with tumor stage and prognosis; MT1-MMP expression, however, was directly correlated with distant metastasis but not with tumor invasion. The gene discussed is TIMP2; the disease is urinary bladder cancer.