Akolekar et al. in 2011 found that the detection rate of preeclampsia in the first trimester by a combination of several markers (PIGF, PAPP-A, PP13, inhibin A, activin A, sEndoglin, PTX3, P-selectin, blood pressure, Dopplersonography, and history) is increased significantly to a detection rate of 91% at a fixed 5% false-positive rate for early-onset PE, 79.4% for intermediate-onset PE (34th–37th weeks of gestation), and 60% for late-onset PE [54]. The gene discussed is PAPPA; the disease is preeclampsia.