H19 and cancer: The first lncRNAs identified were the imprinted H19 gene and X-inactive-specific transcript (XIST) critical to X chromosome inactivation, although at the time of discovery they were not coined “lncRNAs.” Since then, lncRNAs have been associated with Alzheimers, Fragile X Syndrome, blepharophimosis syndrome (BPES), and cancer [46–48].