Further, loss of VCP/p97 accelerates the accumulation of autophagosomes [95], and expression of IBMPFD-linked mutants results in the impaired maturation of autolysosomes with accompanying the cytoplasmic accumulation of TAR DNA-binding protein (TDP-43), a causative gene product for ALS10 and a major constituent of ALS-linked cytoplasmic inclusions [72, 95–97]. This evidence concerns the gene VCP and amyotrophic lateral sclerosis.