In this section, we focus on causative and/or associated genes for ALS/MNDs, whose gene products functionally link to the autophagy-endolysosomal system; including SOD1 [60], FIG4 [61], VCP [62], CHMP2B [63], SQSTM1 [64], DCTN1 [65], DYNC1H1 [66], and RAB7A [67] (Table 1). Here, FIG4 is linked to amyotrophic lateral sclerosis.