Lytic antigens are presented transiently by infected epithelial cells in the lungs, inducing an early peak of the specific CD8 T cells in the lungs but not in the spleen, and since infected epithelial cells are rapidly killed, lytic-antigen specific CD8 T cells show a sharp contraction after control of the lytic infection [154,155,156]. The gene discussed is CD8A; the disease is infection.