Interferon-γ release assays (IGRAs), the QuantiFERON-TB-2 Gold (Cellestis), and T-SPOT.TB (Oxford Immunotec) are noninvasive immunologic diagnostic tests and measure T-cell-induced IFN-γ responses to early secretory antigenic target 6-kD (ESAT-6) protein and culture filtrate protein 10 (CFP-10) as M. Tuberculosis-specific antigens. This evidence concerns the gene IFNG and tuberculosis.