Subsequently, several investigators reported secondary leukemias, particularly acute myelogenous leukemia (AML), associated with translocations of the mixed lineage leukemia (MLL) gene at human chromosomal band 11q23 when etoposide was used to treat lung cancer, non-Hodgkin lymphoma, neuroblastoma, acute lymphoid leukemia (ALL), Wilms tumor, and rhabdomyosarcoma, [3,4,5]. This evidence concerns the gene KMT2A and acute lymphoblastic leukemia.