It is of relevance that the idea of increasing the density of tumor antigen displayed by MHC-II molecules, as it results from our approach of rendering tumor cells MHC-II positive by stable expression of CIITA, has been pursued also by other approaches based, for example, on providing sustained antigenic epitope in endosomal compartments by constructing Invariant chain-antigenic epitope chimeras [39-41] or by treating tumor cells with epigenetic modifiers that increase the expression of tumor-specific shared antigens [42,43]. Here, CIITA is linked to neoplasm.