To the light of these findings and in consideration that an optimal MHC-II-restricted tumor antigen presentation to TH cells can be obtained in different ways, a large series of previously published data on the appearance of an anti-tumor immune response following conventional anti-tumor therapy, may be re-interpreted also as a way to offer sufficient amounts of MHC-bound tumor antigens to the adaptive immune system. The gene discussed is HLA-C; the disease is neoplasm.