We previously analyzed primary ovarian tumors for loss of heterozygosity (LOH) incidence at a panel of four microsatellite markers associated with ovarian cancer-relevant tumor suppressor genes involved in apoptosis, platinum sensitivity and DNA-repair, namely PTEN (marker D10S1765), BRCA1 (marker D13S218), BRCA2 (marker D17S855) and M6P/IGF2R (D6S1581). This evidence concerns the gene PTEN and ovarian cancer.