CDR2 and autoimmune disorder of central nervous system: In addition to VZV infection [2], positive AIs have previously also been reported in individual total-IgG OCB-negative patients with autoimmune disorders of the central nervous system including anti-GAD antibody positive stiff person syndrome [4], anti-Ri positive paraneoplastic neurological syndromes (PNS) [5], anti-CV2/CRMP5 positive PNS [6], and anti-Yo positive PNS [3].