Although we found no marked difference in the frequency of alleles of other ALOX5AP SNPs tested between the control and case groups studied, we found significant differences of genotype frequency of other ALOX5AP SNPs between the control and case subjects, suggesting that they might play a role in the pathogenesis of cerebral infarction in the Han population of northern China. The gene discussed is ALOX5AP; the disease is cerebral infarction.