UCP2 and status epilepticus: It follows that our demonstration of an increase or decrease in mitochondrial UCP2 expression induced by rosiglitazone or GW9662 underlying the attenuation or exacerbation of seizure-induced mitochondrial complex I dysfunction, suggests that another cellular role for UCP2 induced by experimental status epilepticus is amelioration of bioenergetics inefficiency in the hippocampus.