The study focused on antibodies specific for the following immunogenic proteins: (i) outer membrane protein 6 (P6) of H. influenzae, because reduced concentrations of anti-P6 IgG1 antibody are a risk factor for asthma exacerbations in children [9], (ii) pneumococcal surface protein C (PspC), because anti-PspC antibodies can mediate host protection against S. pneumoniae[10], and (iii) a type A conserved rhinovirus outer capsid protein (VP1) as type A rhinoviruses are the most common, and anti-VP1 antibodies exhibit cross-neutralizing activity across different rhinovirus strains in vivo[11]. Here, SFTPC is linked to asthma.