PPARG and thyroid cancer, nonmedullary, 2: Molecular aberrations observed in FTC are significantly different from those described in PTC, including RAS mutations in up to 45% of patients and rearrangements involving the transcription factor gene of the paired-box 8 (PAX8) and peroxisome proliferator-activated receptor-γ(PPARγ) resulting in a PAX8/PPARγ rearrangement observed in up to 35% of FTC [12].