One unique animal model is the Eker rat, which carries a spontaneous germ line mutation of the Tsc2 gene and was initially described as a model for renal cancer [37].Only mild brain pathologies were observed in Tsc2+/− rats, albeit may be more pronounced in aged animals, and—in addition—epileptic seizures were not detected at all [26, 38–40], (Table 1). The gene discussed is TSC2; the disease is renal carcinoma.