Heart weight to tibial length (HW/TL) ratios were significantly increased by Ang II infusion in vehicle-treated mice (9.6 ± 0.5 versus 6.5 ± 0.2 mg/mm; Figure 2(b)), while treatment with CNP decreased this Ang II-induced cardiac hypertrophy by 16%. This evidence concerns the gene CNP and cardiac hypertrophy.