BDNF and lesion of sciatic nerve: Exogenous application of BDNF and preconditioning lesions (where dorsal column injury is preceded by preconditioning sciatic nerve lesions) enhance regeneration of ascending sensory axons but also enhanced functional recovery together with expression of p-CREB, pERK, and GAP-43 after spinal cord injury, indicating that BDNF is anterogradely transported by axons [80].