Along the same lines, ABL1 tyrosine kinase activity was shown to be important for the maintenance of adherens junctions in epithelial cells [37], and S/T phosphorylation of E-cadherin by protein kinase D1 (PRKD1) was found to be associated with increased cellular adhesion and decreased cellular motility in prostate cancer [59]. This evidence concerns the gene PRKD1 and Familial prostate cancer.