These tumors displayed large necrotic areas (as seen in Figure 2B left panel, Figure S2A (control cells) and S2B (22Rv1 shLTR1+2)) and showed significantly fewer vessel numbers when performing immunohistochemical staining applying a CD34 monoclonal antibody to tumor tissue sections (Figure 3A upper panels and Figure 3B) as compared to the controls. This evidence concerns the gene CD34 and neoplasm.