After the original study by Madsen et al in 1998, where MBL deficiency was associated with increased risk for severe atherosclerosis in relatively young patients [6], polymorphisms in MBL2 and serum concentrations of the protein have been linked to both increased and reduced risk of atherosclerosis and coronary artery disease in different populations [7], [8], [9], [10], [11]. The gene discussed is MBL2; the disease is hyperinsulinemic hypoglycemia, familial, 4.