BGLAP and Insulin resistance: The endocrine function of the bone is exerted through the release of a series of hormones and, among them, osteocalcin (OC), a molecule with a role in local bone physiology, but also able to regulate fat and glucose metabolism, insulin secretion and pancreatic β cells proliferation; moreover, in adipocyte, OC induces the release of adiponectin which, in turn, reduces insulin resistance [12], [17], [18].