Considering the role of CRK-II serine phosphorylation on the p120-catenin (CTNND1) transcriptional repression and also promotion of motility and invasiveness in NSCLC cells, we sought to identify the upstream kinase(s) that might mediate CRK-II serine 41 phosphorylation. This evidence concerns the gene CTNND1 and non-small cell lung carcinoma.