CRK and non-small cell lung carcinoma: Considering downregulation of p120-catenin in non-small cell lung cancer (NSCLC) is transcriptionally mediated [11], an investigation in the upstream signaling events that could result in transcriptional repression of p120-catenin (CTNND1), lead us to adaptor protein CRK and its role in the repression of p120-catenin [12].