CFHR1 and hypertensive disorder: Although the molecular mechanism by which the rs2274700 (A473A) and rs7542235 (CFHR1–3Δ) variants contribute to hypertension risk remains unknown, a possible explanation is that the mutations caused by A473A and CFHR1–3Δ may lead to changes in expression or function of CFH and CFHR1/R3, and consequently result in dysregulation of complement system and inflammation.