TP53 and neoplasm: The diverse action mechanisms of the miRNAs-371-373 cluster on various cancer occurrence have been suggested; for example, collaboration with oncogenic Ras and neutralization of p53-mediated cyclin-dependent kinase inhibition [34], promotion of tumor invasion and metastasis by suppression of CD 44 [37], or modulation of Wnt/β-catenin-signaling pathways [38].