In 2004, the Original European Liver Fibrosis panel of serum markers of liver fibrosis incorporates hyaluronic acid (HA), tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), and aminoterminal propeptide of procollagen type III (P3NP), all of which are involved in the synthesis and degradation of the extracellular matrix. This evidence concerns the gene TIMP1 and Hepatic fibrosis.