Overall, the mutation rate for truncating mutations in APC was significantly higher in polypoid adenomas compared to flat adenomas (48.49% (95% CI 37.23%-59.87%) versus 30.27% (95% CI 20.13%-42.05%), respectively, p = 0.02, odds ratio 0.46, 95% CI 0.25%-0.90%, Figure 2, Table S2N). This evidence concerns the gene APC and adenoma.