In total 93 polypoid adenomas and 106 flat adenomas were analyzed for 13 genes (BRAF, NRAS, KRAS, PIK3CA, PIK3R1, EGFR, PTEN, MAP2K4, SMAD4, FBXW7, CTNNB1, STK11 and PDGFRA) at 82 nucleotide positions. The gene discussed is CTNNB1; the disease is adenoma.