Interestingly, we found that the homozygous variant genotypes of both rs2276466 and rs3136038 were indeed associated with increased mRNA expression levels of ERCC4 in EBV-transformed lymphoblastoid cell lines derived from Caucasians, which supports the observed associations of these two homozygous variant genotypes with a decreased risk of SCCHN. The gene discussed is ERCC4; the disease is head and neck squamous cell carcinoma.