IFNG and colitis: However, serum levels of IFN-γ, IL-1α, IL-6, and IL-17 were elevated at baseline in the serum of T/I mice (these mice had colitis at the time of assessment) compared with WT mice and IFN-γ and IL-17 did not significantly increase in the serum of T/I mice following challenge with LPS (Table 3).