TMPRSS11D and Alzheimer disease: Importantly, this finding, in conjunction with our previously published reports supporting a causative role for Tip60 in the control of synaptic plasticity [5] and the transcriptional regulation of genes enriched for neuronal function [4], support the concept that misregulation of Tip60 HAT activity can lead to aberrant gene expression within the nervous system that contributes to the AD associated neurodegenerative process.