Since lungs are the main portal of entry of P. aeruginosa bacteremia and ExoU seems to play an important role in invasive infections, we then investigated whether NF-κB activation and IL-8 secretion induced by ExoU were restricted to airway epithelial cells or could also occur in microvascular endothelial cells. The gene discussed is NFKB1; the disease is bacterial infectious disease with sepsis.